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Big Questions with Cal Fussman

Sep 27, 2022

Morphogenesis has an immunotherapy treatment that has worked in five out of five clinical trials on skin cancer and it’s nasty cousin, Merkel Cell cancer. The company’s CEO, Dr. James Bianco, says that the treatment may work against any cancer. But he doesn’t want anyone calling it The Cancer Vaccine. Cal gets...


Sep 20, 2022

​​Rich Palarea’s introduction on Twitter reads: “I won’t sleep until I fix $ waste in healthcare.” Cal listens to the story of how Rich became CEO of Kermit, a company that uses technological transparency to reduce costs on surgical implants for hospitals. The conversation reveals how little we know about...


Sep 13, 2022

Cal takes a moment to pause and reflect on moments he had with two icons who said farewell recently in very different ways. Tennis great Serena Williams ended one of the most impactful careers in the history of any sport at the U.S. Open and the man who lifted The Iron Curtain, Mikhail Gorbachev, took his final breath...


Aug 30, 2022

Many people have avoided going to the doctor during the time of Covid . . . unless they had Covid. This may have resulted in missing an early detection of cancer. So this podcast is a reminder to all those who’ve delayed checkups to make an appointment. Cal gets an exam, and now has peace of mind. He also puts the...


Aug 23, 2022

Cal has spent his life writing stories and telling them on stage. Big Questions started after he told stories for three straight hours on Tim Ferriss’s podcast. But Cal finds a new power in storytelling through Harvard’s Annie Brewster, a physician who used her own story to help heal herself after being diagnosed...